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ONCOVET L - CHEMOVET 

Lomustine 10 mg, 40 mg, 100 mg - Capsules

Medicine Name: Oncovet L

 

Presentation:

Lomustine 10 mg - capsules

Package: 1 Bottle containing 10 capsules.
 

Lomustine 40 mg - capsules

Package: 1 Bottle containing 10 capsules.

 

Lomustine 100 mg - capsules

Package: 1 Bottle containing 10 capsules.

 


Chemotherapy drug to canine and feline with cancer.
Use in veterinary medicine
Made in Argentina


Description: Chemotherapy for dogs and cats. Composition: Lomustine: 10 mg, 40 mg or 100 mg. Excipients authorized. c.s. 

 

Action: Chemotherapy. The basic idea behind drugs of cancer chemotherapy is for them to reach areas of the body that are inaccessible to surgery and to kill only the cancer cells and leave alone the normal cells of the body. Lomustine is a member of the nitrosurea class of chemotherapy agents, which act by binding DNA to other DNA strands or to protein in such a way that the DNA double helix strand cannot replicate. In addition to essentially tangling DNA up, lomustine generates a by-product that prevents normal DNA function.  

 

Indications: Chemotherapy drug to use in pet with cancer. Lomustine has the ability to penetrate the blood/brain barrier, which means it can be used to treat cancers of the nervous system.  Also the usual tumors against which lomustine is most commonly used are: lymphoma, mast cell tumors, kidney tumors, brain malignant tumors, lung malignant tumors, sarcomas and melanoma.

 

Dosage: Dogs: 60-90 mg/mt2. Cats: 50-60 mg/mt2.

 

Therapeutic regimen: The interval and numbers of cycles should be indicated by a diplomate veterinary oncology.  General rule is between 21-28 days.

 

Side effects: Because lomustine targets rapidly dividing cells, the cells of the bone marrow are vulnerable whether or not there is any cancer. The bone marrow is where blood cells are produced and special attention is generally paid to white blood cells, whose numbers typically drop about a week after the lomustine dose is given. Often antibiotics are given during the week where the white count drops to at least in part make up for the blow to the immune system caused by the drug. Platelets, cells involved in blood clotting, also drop in number with lomustine but generally recover by the time for the next dose. If they have not, the dose may be delayed. Bone marrow effects are more pronounced in cats, thus lower doses of lomustine are typically used. Lomustine is harsh on the patient’s liver as well. Liver disease first manifests as a change in laboratory testing, long (average of 10 weeks) before the patient actually feels ill. To prevent a patient from developing serious liver disease, an enzyme called alanine aminotransferase (ALT) is monitored before each lomustine dose. If there is any elevation, the lomustine treatments are discontinued. No information is available regarding liver toxicity in cats on lomustine, so currently the canine monitoring protocols are recommended for both species.Kidney damage from lomustine is not common but kidney function is usually included in the monitoring. Normal intestinal cells are also rapidly dividing and most chemotherapy agents targeting rapid cell division generally cause an upset stomach. Lomustine is not associated with upset stomach, which poses a tremendous advantage of this drug over others, at least from the patient’s perspective. Other side effects that have been reported include: oral inflammation, scarring of lung tissue, and thinning of the surface of the eye (corneal de-epithelialization). Kidney damage from lomustine is not common but kidney function is usually included in the monitoring. Normal intestinal cells are also rapidly dividing and most chemotherapy agents targeting rapid cell division generally cause an upset stomach. Lomustine is not associated with upset stomach, which poses a tremendous advantage of this drug over others, at least from the patient’s perspective. Other side effects that have been reported include: oral inflammation, scarring of lung tissue, and thinning of the surface of the eye (corneal de-epithelialization).

 

Interactions with Other Drugs: Lomustine is removed from the body by the liver’s detoxification processes within hours of administration. Phenobarbital, the most common oral anti-convulsant in pets, enhances the enzymes involved, which means that pets on phenobarbital will remove lomustine from their bodies faster than they normally would and lomustine will not work as well. Any time two drugs with potential to suppress the bone marrow are used together, the risk of marrow suppression becomes greater. Such drugs would include other agents of chemotherapy, chloramphenicol, possibly methimazole, etc. Any time two drugs that have potential to suppress immune function are used together, the risk of infection becomes greater. Such drugs would include other agents of chemotherapy and corticosteroids.

 

Concerns and Cautions: As with all chemotherapy agents, lomustine should not be used in pregnancy, lactation, or in animals to be used for breeding. Live vaccinations should not be given while the patient is on lomustine.

 

 

Our experienced veterinarians are committed to staying on the cutting edge of innovative technology and products. We use only the most advanced veterinary medicine to treat our furry patients. 

9 de Julio 3875, Lanús, Buenos Aires, Argentina

Contact: chemovet@chemovet.org

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